Stockbrügger R, Angervall L, Lundqvist G
Scand J Gastroenterol. 1976;11(7):713-9.
Forty-two patients with pernicious anemia (PA) and 35 patients with achlorhydria but without PA were investigated by means of serum gastrin determination and estimation of circulating parietal cell and thyroidal autoantibodies. In 38 of the 77 patients, gastroscopic and histopathological examinations of the antral and corpus mucosa were performed. The patient groups were similar with regard to distribution of high and normal serum gastrin levels, the frequencey of autoantibodies and antrum-sparing atrophic gastritis. In the present selection of patients, therefore, the achlorhydria group was supposed to represent a precursor state of the group with PA. A minor proportion of patients with severe atrophic gastritis of the antrum as well as of the corpus mucosa was found in the two groups.
通过血清胃泌素测定以及循环壁细胞和甲状腺自身抗体的评估，对42例恶性贫血（PA）患者和35例胃酸缺乏但无PA的患者进行了研究。在这77例患者中的38例中，对胃窦和胃体黏膜进行了胃镜检查和组织病理学检查。两组患者在高血清胃泌素水平和正常血清胃泌素水平的分布、自身抗体的频率以及胃窦保留性萎缩性胃炎方面相似。因此，在本研究选择的患者中，胃酸缺乏组被认为代表了PA组的前驱状态。在两组中均发现了一小部分胃窦以及胃体黏膜有严重萎缩性胃炎的患者。
