Peter H J, Zapf J, Froesch E R, Eppenberger H, Bernhard K, Hossli G
Schweiz Med Wochenschr. 1976 Jul 17;106(29):987-91.
Creatinphosphokinase (CPK) was elevated in sera of patients with malignant hyperthermia and in sera of some of their relatives. Only the MM-isoenzyme (but not the MB- or the BB-isoenzyme) could be detected by paperchromatographic analysis. In some of the patients elevation of muscle aldolase was also observed. Thus, the appearance of the BB-isoenzyme in sera of patients with malignant hyperthermia, as described by another group of investigators, was not confirmed. No specific screening method exists as yet to detect patients with a high risk of developing this often lethal reaction to anesthesia. However, in patients without muscle disease or trauma and without prior i.m. injections, myocardial infarction or major physical strain, elevation of CPK in serum should be interpreted as meaning that malignant hyperthermia may develop during anesthesia. The pathophysiology of malignant hyperthermia is discussed.
恶性高热患者及其部分亲属的血清中肌酸磷酸激酶（CPK）升高。通过纸色谱分析仅能检测到MM同工酶（而非MB或BB同工酶）。在部分患者中还观察到肌肉醛缩酶升高。因此，另一组研究人员所描述的恶性高热患者血清中出现BB同工酶的情况未得到证实。目前尚无特异性筛查方法来检测具有发生这种常为致命性麻醉反应高风险的患者。然而，对于无肌肉疾病或创伤、无既往肌肉注射、心肌梗死或重大体力负荷的患者，血清CPK升高应被解释为意味着在麻醉期间可能发生恶性高热。本文讨论了恶性高热的病理生理学。
