在密码子-反密码子配对中是否存在对摆动的选择作用？
Is there selection against wobble in codon-anticodon pairing?
作者信息
Fitch W M
出版信息
Science. 1976 Dec 10;194(4270):1173-4. doi: 10.1126/science.996548.
PMID:996548
Abstract
Among amino acid codons that require a third-position pyrimidine, there is a significant bias favoring the use of cytidine over uracil in MS2 phage RNA. This could arise from selection against wobble pairing in the interaction of transfer RNA and messenger RNA. Among amino acid codons with fourfold degeneracy, there is a bias favoring pyrimidines over purines.
摘要
在需要第三位嘧啶的氨基酸密码子中，MS2噬菌体RNA中存在显著偏向，更倾向于使用胞嘧啶而非尿嘧啶。这可能源于在转运RNA与信使RNA相互作用中对摆动配对的选择。在具有四重简并性的氨基酸密码子中，存在偏向嘧啶而非嘌呤的情况。
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