Matowicka-Karna J, Panasiuk A, Kemona H
Institute of Laboratory Diagnostics, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1998;43:110-6.
Platelets are part of body defence system, especially the antiparasite immunologic response. Platelets manifest their functions only after their activation. Thrombin activates platelets inducing change of their shape and causing secretion of certain substances. This study was designed to estimate blood platelets morphology as an indicator of their activation and effectiveness of antiparasite therapy. The study was conducted in group of 21 patients infected with T.spiralis before treatment (T1) and group of 19 patients after two weeks of treatment (T2). The diagnosis of trichinellosis was established on the bases of epidemiologic history, clinical picture and immunologic investigations. In the course of trichinellosis and after antiparasitic treatment increase of blood platelet count was observed. The decreased mean platelets volume observed in trichinellosis may be connected with their activation and releasing platelet factor 4 and beta-thromboglobulin. We suggest that T.spiralis activates platelets and the degree of their activation determines their morphologic parameters.
血小板是机体防御系统的一部分，尤其是在抗寄生虫免疫反应中。血小板只有在被激活后才会发挥其功能。凝血酶激活血小板，导致其形状改变并促使某些物质分泌。本研究旨在评估血小板形态，以此作为其激活及抗寄生虫治疗效果的指标。研究针对21例旋毛虫感染患者治疗前（T1）和19例治疗两周后的患者（T2）进行。旋毛虫病的诊断基于流行病学病史、临床表现及免疫学检查。在旋毛虫病病程中及抗寄生虫治疗后，观察到血小板计数增加。旋毛虫病中观察到的平均血小板体积减小可能与其激活及血小板因子4和β-血小板球蛋白的释放有关。我们认为，旋毛虫激活血小板，其激活程度决定了血小板的形态学参数。
