Mantur M, Matowicka-Karna J, Darewicz B, Kemona H, Dymicka-Piekarska V, Prokopowicz J, Darewicz J
Institute of Laboratory Diagnostics, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1998;43:292-7.
The main role of neutrophilic granulocytes is phagocytosis and destruction of phagocytized bacteria. The nitroblue tetrazolium test (NBT), used to evaluate the bactericidal function of granulocytes, was assessed in 45 patients with renal tumour before and 14 days after renal artery embolization. No statistically significant spontaneous test NBT differences were found, compared with control group both before and 14 days after embolization. Following stimulation granulocytes in vitro by LPS of E. coli the ability of granulocytes to reduce NBT was lowered. The differences, as compared with control group, were statistically significant (p < 0.05). Our results indicates considerable impairment of lower metabolic reserve in patients with renal tumour necessary for maximum stimulation.
嗜中性粒细胞的主要作用是吞噬和破坏被吞噬的细菌。用硝基四氮唑蓝试验（NBT）来评估粒细胞的杀菌功能，对45例肾肿瘤患者在肾动脉栓塞术前及术后14天进行了该试验。与栓塞术前及术后14天的对照组相比，未发现NBT试验的自发差异有统计学意义。在体外用大肠杆菌脂多糖刺激粒细胞后，粒细胞还原NBT的能力降低。与对照组相比，差异有统计学意义（p<0.05）。我们的结果表明，肾肿瘤患者在最大刺激时所需的较低代谢储备有相当大的损害。
