Mantur M, Matowicka-Karna J, Darewicz B, Kemona H, Dymicka-Piekarska V, Prokopowicz J, Darewicz J
Institute of Laboratory Diagnostics, Medical University, Białystok, Poland.
Neoplasma. 1998;45(3):148-50.
The aim of the study was to determine the effect of renal tumor embolization on nonspecific immunity by evaluating lysozyme activity and leucocytosis in 45 patients and 40 healthy people. Lysozyme activity was assessed in the non-diluted serum (A1) and in the tenfold diluted serum (B1) prior to embolization and after embolization (A2, B2) and in control group. Prior to embolization, lysozyme activity was lower in the experimental group (A1 and B1), compared to the control groups, the differences being statistically significant (p < 0.05). After embolization, the activity became normalized (A2), reaching the control value and even exceeding it (C) in the diluted serum (B2). Leucocytosis prior to embolization (L1) resembled that of control group, increasing slightly after embolization (L2). The differences observed in the changes in lysozyme activity and leucocytosis were statistically significant (p < 0.05). Our findings indicate an inhibitory effect of the neoplastic process on nonspecific immunity. Embolization causes ischemic necrosis of tumor and products of neoplastic tissue disintegration exert a stimulating effect on granulopoiesis, by increasing the turnover of neutrophilic granulocytes. Granulocytic-monocytic infiltrations in tumor stroma are the source of lysozyme, enhancing not only local but also systemic immunity, which is manifested in the increased lysozyme activity in blood serum.
本研究的目的是通过评估45例患者和40名健康人的溶菌酶活性和白细胞增多情况，来确定肾肿瘤栓塞对非特异性免疫的影响。在栓塞前和栓塞后，对未稀释血清（A1）、十倍稀释血清（B1）、未稀释血清（A2）、十倍稀释血清（B2）以及对照组血清进行溶菌酶活性评估。栓塞前，与对照组相比，实验组（A1和B1）的溶菌酶活性较低，差异具有统计学意义（p < 0.05）。栓塞后，活性恢复正常（A2），在稀释血清（B2）中达到并甚至超过对照组水平（C）。栓塞前的白细胞增多情况（L1）与对照组相似，栓塞后略有增加（L2）。溶菌酶活性和白细胞增多变化的差异具有统计学意义（p < 0.05）。我们的研究结果表明肿瘤进程对非特异性免疫具有抑制作用。栓塞导致肿瘤缺血坏死，肿瘤组织崩解产物通过增加中性粒细胞的周转率，对粒细胞生成产生刺激作用。肿瘤基质中的粒细胞 - 单核细胞浸润是溶菌酶的来源，不仅增强局部免疫，还增强全身免疫，这表现为血清中溶菌酶活性增加。
