Sulik M, Piłat-Marcinkiewicz B, Sulik A, Barwijuk-Machała M, Sulkowska M, Baltaziak M, Klepacka J
Department of Pathological Anatomy, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1998;43:298-308.
The fetotoxic effect of 2,4-dichlorophenoxyacetic acid (2,4-D) was investigated. Histological and histochemical changes in the liver of newborn, jung and adult rats exposed to the herbicide from the prenatal period to the end of an experiment were evaluated. The experiment used 90 male and female, Wistar, aged to 10 weeks rats, divided into two groups: I-control-30 and II-60 animals which received the water solution of 2,4-D acid sodium salt in a daily dose of 250 mg/kg b.w. It was given with drinking water every day. The animals were sacrificed after 24 hours, 4, 6, and 10 weeks of the experiment. The results obtained showed that the administration of 2,4-D acid to rats in the prenatal and postnatal period, in a dose inducing subacute intoxication leads to histological and histochemical changes in the liver. The observed changes indicate disorders in energetic processes in hepatocytes and are morphological exponents of detoxicative processes there. They are most intensified with newborn rats. It suggest also, the pregnants ought not to work with 2,4-D and should avoid any contact with herbicides belongs to the 2,4-dichlorophenoxyacetic acid group.
研究了2,4-二氯苯氧乙酸（2,4-D）的胚胎毒性作用。评估了从孕期到实验结束暴露于该除草剂的新生、幼年和成年大鼠肝脏的组织学和组织化学变化。实验使用了90只10周龄的Wistar雌雄大鼠，分为两组：I组为对照组，30只；II组为60只，接受每日剂量为250mg/kg体重的2,4-D酸钠盐水溶液，每天随饮用水给予。在实验的24小时、4周、6周和10周后处死动物。所得结果表明，在产前和产后给大鼠施用2,4-D酸，剂量诱导亚急性中毒会导致肝脏的组织学和组织化学变化。观察到的变化表明肝细胞能量代谢过程紊乱，是那里解毒过程的形态学指标。新生大鼠的这些变化最为明显。这也表明，孕妇不应接触2,4-D，应避免与属于2,4-二氯苯氧乙酸组的任何除草剂接触。
