Sato I, Parry B W
Department of Veterinary Science, University of Melbourne, Werribee, Victoria.
Aust Vet J. 1998 Dec;76(12):809-12. doi: 10.1111/j.1751-0813.1998.tb12332.x.
To determine the effect of 1-Deamino-8-D-arginine vasopressin on plasma concentrations of von Willebrand factor and factor VIII in Greyhound blood donors, and to compare the response of 1-Deamino-8-D-arginine vasopressin injection on plasma concentrations of von Willebrand factor between groups with different resting plasma concentrations of von Willebrand factor.
Fifteen Greyhound blood donors were used. Dogs were grouped into three categories depending on their von Willebrand factor concentrations.
Desmopressin was administered subcutaneously at 1 microgram/kg [corrected] to all dogs. Plasma von Willebrand factor and factor VIII concentrations were measured before and 10, 20, 30, 45, 60, 90 and 120 min after desmopressin injection.
The von Willebrand factor and factor VIII concentrations in all dogs increased significantly and remained higher than base-line throughout the 2 h period.
Desmopressin is useful in increasing von Willebrand factor concentrations in Greyhound blood donors, including those with low resting concentrations.
确定1-去氨基-8-D-精氨酸加压素对灵缇犬献血者血浆血管性血友病因子（von Willebrand factor）和凝血因子VIII浓度的影响，并比较不同静息血浆血管性血友病因子浓度组间1-去氨基-8-D-精氨酸加压素注射对血浆血管性血友病因子浓度的反应。
使用15只灵缇犬献血者。根据其血管性血友病因子浓度将犬分为三类。
对所有犬皮下注射去氨加压素，剂量为1微克/千克[校正后]。在去氨加压素注射前以及注射后10、20、30、45、60、90和120分钟测量血浆血管性血友病因子和凝血因子VIII浓度。
所有犬的血管性血友病因子和凝血因子VIII浓度均显著升高，并且在整个2小时期间均高于基线水平。
去氨加压素可有效提高灵缇犬献血者的血管性血友病因子浓度，包括那些静息浓度较低的犬。
