血管生成：治疗干预的可能性

Angiogenesis: possibilities for therapeutic interventions.

作者信息

Wynendaele W, van Oosterom A T, Pawinski A, de Bruijn E A, Maes R A

机构信息

Laboratory of Experimental Oncology (LEO), Leuven, Belgium.

出版信息

Pharm World Sci. 1998 Dec;20(6):225-35. doi: 10.1023/a:1008600603059.

DOI:10.1023/a:1008600603059

PMID:9972522

Abstract

Vascular proliferation normally occurs only during embryonic development, the female reproductive cycle and wound healing. Various pathological conditions such as diabetic retinopathy are characterized by persistent, uncontrolled angiogenesis. At the other hand, impaired development of new blood vessels has been found to be related with myocardial infarction. A series of anti-angiogenic drugs are currently included in experimental cancer treatment, whereas the failure of ulcers to heal may be limited by increased angiogenesis upon administration of growth factors. In the present review control mechanisms of the vasculature are summarized and therapeutic approaches discussed.

摘要

血管增殖通常仅发生在胚胎发育、女性生殖周期和伤口愈合过程中。各种病理状况，如糖尿病性视网膜病变，其特征是持续性、不受控制的血管生成。另一方面，已发现新生血管发育受损与心肌梗死有关。目前，一系列抗血管生成药物被纳入癌症实验治疗中，而溃疡愈合失败可能会因给予生长因子后血管生成增加而受到限制。在本综述中，总结了脉管系统的调控机制并讨论了治疗方法。