Wood R D, Shen E H, Chester J A, Phillips T J
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health Sciences University, 97201, USA.
Pharmacol Biochem Behav. 1999 Feb;62(2):339-47. doi: 10.1016/s0091-3057(98)00158-0.
The replicate lines of selectively bred FAST and SLOW mice differ in locomotor response to 2 g/kg ethanol (EtOH). FAST mice show enhanced locomotion; SLOW mice exhibit no change or locomotor depression. Little is known about the responses of FAST and SLOW mice to EtOH during development. We assessed the locomotor responses of FAST and SLOW mice at postnatal days (P) 10, 15, 30, and 60. A genetically correlated response, EtOH-induced hypothermia, was also investigated. Although all animals demonstrated their respective selection phenotypes in adulthood, developing FAST mice exhibited ethanol stimulation by P15 (replicate 1) or P30 (replicate 2). At these ages, responses of FAST mice differed from those of SLOW. The stimulant response in FAST mice was adult-like at P30. EtOH-induced hypothermia was seen in SLOW mice by P15. These data suggest that sensitivity to the locomotor stimulant effects of EtOH changes during postnatal development, and may mirror developmental profiles for certain neurotransmitter systems.
经选择性培育的快速型和慢速型小鼠的复制品系，对2克/千克乙醇（EtOH）的运动反应有所不同。快速型小鼠表现出运动增强；慢速型小鼠则无变化或运动抑制。关于快速型和慢速型小鼠在发育过程中对乙醇的反应，人们了解甚少。我们评估了快速型和慢速型小鼠在出生后第10天、15天、30天和60天的运动反应。还研究了一种基因相关反应，即乙醇诱导的体温过低。尽管所有动物在成年后都表现出各自的选择表型，但发育中的快速型小鼠在出生后第15天（复制品系1）或第30天（复制品系2）就表现出乙醇刺激。在这些年龄段，快速型小鼠的反应与慢速型小鼠不同。快速型小鼠在出生后第30天的刺激反应与成年时相似。慢速型小鼠在出生后第15天出现乙醇诱导的体温过低。这些数据表明，出生后发育过程中对乙醇运动刺激作用的敏感性会发生变化，并且可能反映某些神经递质系统的发育情况。
