Willford J A, Segar T M, Hansen-Trench L S, Barron S
Psychology Department, University of Kentucky, Lexington 40506-0044, USA.
Pharmacol Biochem Behav. 1999 Jan;62(1):137-43. doi: 10.1016/s0091-3057(98)00130-0.
This study examined the effects of neonatal cocaine exposure on the rewarding properties of play in a modified T-maze. Animals were artificially reared from postnatal day (PND) 4-9 with drug concentrated in four daily feeds. There were four treatment groups, 40 mg/kg/day cocaine, 20 mg/kg/day cocaine, an artificially reared control and a surgery control. From PND 38-42, subjects were tested with a food reward (EXP 1) or a play reward (EXP 2). No deficits in learning were seen when the reward was food. The 20 mg/kg/day cocaine group, however, showed impaired learning and altered play behavior when the reward was access to a play partner. Neonatal cocaine exposure thus appears to differentially affect learning based on the type of reward presented.
本研究在改良的T迷宫中考察了新生期接触可卡因对玩耍奖赏特性的影响。动物从出生后第4天至第9天进行人工饲养，药物集中在每日四次喂食中。有四个治疗组，分别为每天40毫克/千克可卡因组、每天20毫克/千克可卡因组、人工饲养对照组和手术对照组。从出生后第38天至第42天，对实验对象进行食物奖赏测试（实验1）或玩耍奖赏测试（实验2）。当奖赏为食物时，未观察到学习缺陷。然而，当奖赏是与玩耍伙伴接触时，每天20毫克/千克可卡因组显示出学习受损和玩耍行为改变。因此，新生期接触可卡因似乎根据所呈现的奖赏类型对学习产生不同影响。
