Taglione E, Vatteroni M L, Martini P, Galluzzo E, Lombardini F, Delle Sedie A, Bendinelli M, Pasero G, Bencivelli W, Riente L
Department of Biomedicine, University of Pisa, Italy.
J Rheumatol. 1999 Feb;26(2):370-2.
To study the prevalence of hepatitis C virus (HCV) infection in 2 groups of patients, one group with psoriasis and the other with psoriatic arthritis (PsA).
We detected anti-HCV antibodies by ELISA and by a recombinant immunoblot assay (RIBA) in the sera of 50 patients with psoriasis and 50 with PsA. As controls we used a group of 76 patients with rheumatoid arthritis (RA), and referred to data on the prevalence of HCV in the general Italian population.
By ELISA, anti-HCV antibodies were detected in 6/50 (12%) patients with PsA, in 5/50 (10%) patients with psoriasis, and in 4/76 (5.2%) patients with RA. All the reactive PsA and RA sera also tested positive on RIBA, while only 3 of the 5 positive results for sera of patients with psoriasis were confirmed by RIBA. The prevalence of HCV infection in patients with psoriasis was not significantly higher than in controls. In contrast, the rate of HCV infection observed in the 50 patients with PsA was higher than that in the other groups, the difference being statistically significant between patients with PsA and the general population.
Our data do not support the hypothesis that HCV infection may play a role in the pathogenesis of psoriasis. On the other hand they show a statistically significant difference between the prevalence of HCV infection in patients with PsA and the general population.
研究两组患者中丙型肝炎病毒（HCV）感染的患病率，一组为银屑病患者，另一组为银屑病关节炎（PsA）患者。
我们采用酶联免疫吸附测定（ELISA）和重组免疫印迹法（RIBA）检测了50例银屑病患者和50例PsA患者血清中的抗HCV抗体。我们将一组76例类风湿关节炎（RA）患者作为对照，并参考了意大利普通人群中HCV感染率的数据。
通过ELISA检测，在50例PsA患者中有6例（12%）、50例银屑病患者中有5例（10%）以及76例RA患者中有4例（5.2%）检测到抗HCV抗体。所有反应性的PsA和RA血清在RIBA检测中也呈阳性，而银屑病患者血清的5个阳性结果中只有3个经RIBA确认。银屑病患者中HCV感染的患病率并不显著高于对照组。相比之下，在50例PsA患者中观察到的HCV感染率高于其他组，PsA患者与普通人群之间的差异具有统计学意义。
我们的数据不支持HCV感染可能在银屑病发病机制中起作用这一假说。另一方面，它们显示PsA患者中HCV感染的患病率与普通人群之间存在统计学上的显著差异。
