Batanian J R, Dunphy C H, Wall D A
Department of Pediatrics, St. Louis University School of Medicine, MO 63104, USA.
Cancer Genet Cytogenet. 1999 Jan 15;108(2):149-53. doi: 10.1016/s0165-4608(98)00134-4.
Jumping translocation is a rare phenomenon, seldom reported to occur in cancer. A complex four-way translocation involving chromosomes 3, 9, 15, and 17 was identified in the chromosome study on a patient with a history of an acute promyelocytic leukemia (APL). In the follow-up studies, the same complex rearrangement exhibited a jumping translocation between chromosomes 3 and 9 in one clone and 3 and 6 in another clone. This is the first reported case of jumping translocation in APL.
跳跃易位是一种罕见现象，很少有报道称其在癌症中发生。在对一名有急性早幼粒细胞白血病（APL）病史的患者进行的染色体研究中，发现了一种涉及3号、9号、15号和17号染色体的复杂的四向易位。在后续研究中，同样的复杂重排在一个克隆中表现为3号和9号染色体之间的跳跃易位，在另一个克隆中表现为3号和6号染色体之间的跳跃易位。这是首次报道的APL中的跳跃易位病例。
