Acar H, Ecirli S, Gündoğan F, Bulay O, Acar A
Department of Medical Genetics, Selçuk University, Konya, Turkey.
Cancer Genet Cytogenet. 1999 Jan 15;108(2):171-4. doi: 10.1016/s0165-4608(98)00116-2.
We describe a case with the simultaneous occurrence of chronic myelogenous leukemia (CML) and non-Hodgkin lymphoma (NHL). Peripheral blood (PB) and bone marrow (BM) smears showed typical CML features. Lymph node biopsy exhibited a large-cell NHL. The Philadelphia chromosome or its molecular counterpart, the BCR-ABL gene fusion, by detecting with dual color-(DC) fluorescence in situ hybridization (FISH), was detected reliably both in metaphase spreads from BM and in interphase nuclei from BM and follow-up PB cells, but was not detected in the lymph node cells. Clinical features and laboratory findings show this case having a coexistence of CML and NHL.
我们描述了一例同时发生慢性粒细胞白血病（CML）和非霍奇金淋巴瘤（NHL）的病例。外周血（PB）和骨髓（BM）涂片显示典型的CML特征。淋巴结活检显示为大细胞NHL。通过双色（DC）荧光原位杂交（FISH）检测，费城染色体或其分子对应物BCR-ABL基因融合，在BM中期分裂相以及BM和随访PB细胞的间期核中均能可靠检测到，但在淋巴结细胞中未检测到。临床特征和实验室检查结果表明该病例存在CML和NHL并存的情况。
