Pomper M G, Miller T J, Stone J H, Tidmore W C, Hellmann D B
Department of Radiology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205, USA.
AJNR Am J Neuroradiol. 1999 Jan;20(1):75-85.
MR findings in CNS vasculitis and their correlation with angiography have not been clearly defined. We therefore explored three hypotheses regarding CNS vasculitis associated with autoimmune disease: 1) MR imaging is highly sensitive; 2) a typical MR appearance exists; and, 3) MR and angiographic findings correlate well.
We studied 18 patients with CNS vasculitis associated with autoimmune disease, characterized the MR lesions by type, size, number, and location, and correlated the MR findings with those of angiography.
All patients with CNS vasculitis had abnormalities on MR studies. On average, four +/- two lesions per patient were detected on MR images. The lesions were located in the subcortical white matter (n = 20), cortical gray matter (n = 16), deep gray matter (n = 16), deep white matter (n = 9), and cerebellum (n = 9). Only 65% of MR lesions were evident on angiograms; 44% of the lesions revealed on angiograms were detected by MR.
MR imaging is sensitive for CNS vasculitis. Lesions attributable to CNS vasculitis in autoimmune disease are distributed nearly equally among cortical, subcortical, and deep gray matter structures. The modest correlation between MR imaging and angiography suggests that the two techniques provide different information about CNS vasculitis and that both types of studies are needed for the complete assessment of damage caused by vascular abnormalities.
中枢神经系统血管炎的磁共振成像（MR）表现及其与血管造影的相关性尚未明确界定。因此，我们探讨了关于自身免疫性疾病相关中枢神经系统血管炎的三个假设：1）MR成像具有高度敏感性；2）存在典型的MR表现；3）MR和血管造影结果具有良好的相关性。
我们研究了18例自身免疫性疾病相关中枢神经系统血管炎患者，按类型、大小、数量和位置对MR病变进行特征描述，并将MR结果与血管造影结果进行相关性分析。
所有中枢神经系统血管炎患者的MR检查均有异常。平均每位患者的MR图像上检测到4±2个病变。病变位于皮质下白质（n = 20）、皮质灰质（n = 16）、深部灰质（n = 16）、深部白质（n = 9）和小脑（n = 9）。血管造影仅显示65%的MR病变；血管造影显示的病变中，44%可通过MR检测到。
MR成像对中枢神经系统血管炎敏感。自身免疫性疾病中由中枢神经系统血管炎引起的病变在皮质、皮质下和深部灰质结构中分布几乎相等。MR成像与血管造影之间的适度相关性表明，这两种技术提供了关于中枢神经系统血管炎的不同信息，并且两种类型的研究对于全面评估血管异常造成的损害都是必需的。
