Beniwal R K, Sharma R D, Nichani A K
Department of Veterinary Medicine, Chaudhary Charan Singh Haryana Agricultural University, Hisar, India.
Trop Anim Health Prod. 1998 Dec;30(6):341-9. doi: 10.1023/a:1005140620390.
The susceptibility/immune status to tropical theileriosis of calves born of immunized dams was evaluated. Six cows were vaccinated with the Theileria annulata cell culture vaccine in the eighth month of pregnancy. Sera from the immunized dams exhibited very high post-vaccination antibody titres as determined by the indirect fluorescent antibody (IFA) test. The calves born to these dams did not show antibodies against T. annulata at the time of birth (IFA titres of < 1:20). The new-born calves were fed colostrum from their mothers and were challenged with T. annulata-infected ground tick supernate at 5-7 days of age. All the calves developed fever (from day 5-6 onwards) and parasitological reactions (from day 8-9 onwards) after challenge. There was a significant decrease in the haemoglobin and packed cell volume of the calves after challenge. All the calves showed signs of acute theileriosis by day 9-10 after challenge and had to be treated with buparvaquone in order to save their lives. The study indicated that detectable levels of anti-theilerial antibodies were not transferred from immune dams to their offspring. All the calves born to immunized dams were fully susceptible to theileriosis and thus themselves needed vaccination.
对免疫母牛所产犊牛的热带泰勒虫病易感性/免疫状态进行了评估。6头母牛在妊娠第8个月接种了环形泰勒虫细胞培养疫苗。通过间接荧光抗体（IFA）试验测定，免疫母牛的血清在接种疫苗后呈现出非常高的抗体滴度。这些母牛所产犊牛在出生时未显示出针对环形泰勒虫的抗体（IFA滴度<1:20）。新生犊牛食用来自其母亲的初乳，并在5 - 7日龄时用感染环形泰勒虫的地面蜱上清液进行攻毒。攻毒后所有犊牛均出现发热（从第5 - 6天起）和寄生虫学反应（从第8 - 9天起）。攻毒后犊牛的血红蛋白和红细胞压积显著下降。攻毒后第9 - 10天，所有犊牛均表现出急性泰勒虫病症状，为挽救其生命，不得不使用丁萘脒进行治疗。该研究表明，可检测水平的抗泰勒虫抗体未从免疫母牛转移至其后代。免疫母牛所产的所有犊牛对泰勒虫病均完全易感，因此它们自身需要接种疫苗。
