使用环形泰勒虫淋巴母细胞降低犊牛抗热带泰勒虫病免疫接种的疫苗剂量。

Lowered vaccine dose for immunisation of calves against tropical theileriosis using Theileria annulata lymphoblasts.

作者信息

Grewal A S, Singh A, Kumar S, Kondal J K, Kanwar J R, Kapur J, Sawhney S M

机构信息

Department of Immunology, Punjab Agricultural University, Ludhiana, India.

出版信息

Trop Anim Health Prod. 1997 Nov;29(4 Suppl):104S-108S. doi: 10.1007/BF02632946.

DOI:10.1007/BF02632946

PMID:9512754

Abstract

Bovine tropical theileriosis is of high incidence in calves below 2 months old in India. The Theileria cell culture vaccine evolved by the Punjab Agricultural University (PAU) was evaluated previously for its efficiency and safety in younger calves, both experimentally and in the field. The dose of cells used for vaccination was regulated at 1.75 to 2 x 10(6) cells. This study, which was undertaken to assess the minimum number of cells which would be effective and safer for vaccination, showed that optimal protection was given by a dose of 1 x 10(6) cells.

摘要

牛热带泰勒虫病在印度2月龄以下犊牛中发病率很高。旁遮普农业大学（PAU）研发的泰勒虫细胞培养疫苗，此前已在幼龄犊牛中通过实验和田间试验对其有效性和安全性进行了评估。用于疫苗接种的细胞剂量规定为1.75至2×10⁶个细胞。本研究旨在评估对疫苗接种有效且更安全的最低细胞数量，结果表明1×10⁶个细胞的剂量可提供最佳保护。