Husslein H
Wien Klin Wochenschr. 1976 Nov 26;88(22):729-32.
The paper reports the therapeutic results achieved in patients attending the sterility clinic over the period 1969-1974. Altogether 540 couples were examined and treated. The average age of the female patients in this series was 29,6 years; the length of time over which pregnancy had been attempted averaged 3.9 years. Sterility was attributable to the female partner in 54.3% of the cases, to the male partner in 32.4% and to both spoused in 3%. No apparent cause for the sterility was detected in 10.3% of the cases. 209 pregnancies occurred following treatment, corresponding to an overall success rate of 38.7%, or 40.6% when due allowance is made for the 27 cases in whom the outlook was certainly hopeless. 107 husbands were treated and in 22 cases (20.5%) their spouses became pregnant during the period of treatment. The following therapeutic measures proved successful in the females: clomiphene: 34 pregnancies in 82 patients; gonadotrophins (HMG), HCG): 13 pregnancies in 35 patients; 22 out of 66 patients becamse pregnant had been discontinued; treatment of luteal insufficiency with Duphaston resulted in 13 pregnancies among 43 women; tubal surgery led to eight pregnancies in 32 patients and uterine surgery to one pregnancy among five patients. The greatest number of pregnancies was achieved by simple therapeutic measures such as consultation, determination of the optimum time for conception, local treatment, and cervical dilatation.
该论文报告了1969年至1974年期间在不育诊所就诊的患者的治疗结果。总共对540对夫妇进行了检查和治疗。该系列女性患者的平均年龄为29.6岁;尝试怀孕的平均时间为3.9年。在54.3%的病例中,不育归因于女性伴侣,32.4%归因于男性伴侣,3%归因于夫妻双方。在10.3%的病例中未发现不育的明显原因。治疗后发生了209次妊娠,总体成功率为38.7%,如果考虑到27例肯定无望受孕的病例,成功率为40.6%。对107名丈夫进行了治疗,其中22例(20.5%)的配偶在治疗期间怀孕。以下治疗措施对女性患者有效:克罗米芬:82例患者中有34例怀孕;促性腺激素(HMG、HCG):35例患者中有13例怀孕;66例已停药的患者中有22例怀孕;用达芙通治疗黄体功能不全,43名女性中有13例怀孕;输卵管手术使32例患者中有8例怀孕,子宫手术使5例患者中有1例怀孕。通过诸如咨询、确定最佳受孕时间、局部治疗和宫颈扩张等简单治疗措施实现了最多的妊娠。