Schier J, Kluciński W, Sitarska E, Rudowski W, Daszyński J, Mościcka M
Z Exp Chir. 1976;9(2):120-8.
The ability of stroma-free haemoglobin solutions to transport oxygen was investigated by determining the oxygen consumption by the liver using Warburg's microrespirator. 50 ml of blood were removed from the rabbit under general anaesthesia and replaced by an identical volume of a non-oxygenated or oxygenated haemoglobin solution. The control rabbits received no transfusions. It was found that arterial hypotension produced by blood-letting caused a significant rise in oxygen consumption by the hepatic tissue. The rise was increased even more when the rabbits received no transfusions. Transfusion of non-oxygenated haemoglobin solutions caused likewise a rise in oxygen consumption immediately after transfusion. This rise was, however, not so significant as in the control group. On the other hand, transfusion of oxygenated haemoglobin solutions produced no rise in the oxygen consumption by the liver as compared to its value after blood-letting.
通过使用瓦尔堡微量呼吸计测定肝脏的耗氧量，研究了无基质血红蛋白溶液运输氧气的能力。在全身麻醉下从兔子身上抽取50毫升血液，并用相同体积的未氧合或氧合血红蛋白溶液代替。对照兔子未接受输血。发现放血引起的动脉低血压导致肝组织耗氧量显著增加。当兔子未接受输血时，这种增加更为明显。输注未氧合血红蛋白溶液同样在输血后立即导致耗氧量增加。然而，这种增加不如对照组显著。另一方面，与放血后的肝脏耗氧量相比，输注氧合血红蛋白溶液并未使其增加。
