Wedell J W, Fritsch P, Hausamen T U
Z Gastroenterol. 1976 Oct;14(6):620-5.
In 10 healthy controls, in 3 patients with subtotal resection of the small intestine and in 7 patients with jejuno-ileal bypass gastric ackd secretion and serum gastrin were determined in the basal state and after stimulation. The patients with short bowel revealed basal and pentagastrin stimulated gastric acid secretion in the lower normal range. Hypergastrinaemia, however, was present in these patients in the basal state and after food stimulation of gastrin release, while in patients with jejuno-ileal bypass basal and postprandial serum gastrin concentrations were within the normal range. These data suggest, that hypergastrinaemia in patients with short bowel is due to dimished gastrin catabolism and that the small intestine plays a significant role in gastrin inactivation.
在10名健康对照者、3名小肠次全切除患者和7名空肠回肠旁路术患者中，测定了基础状态及刺激后胃酸分泌和血清胃泌素水平。短肠患者基础状态及五肽胃泌素刺激后的胃酸分泌处于正常低限范围。然而，这些患者在基础状态及进食刺激胃泌素释放后存在高胃泌素血症，而空肠回肠旁路术患者基础及餐后血清胃泌素浓度在正常范围内。这些数据提示，短肠患者的高胃泌素血症是由于胃泌素分解代谢减弱，且小肠在胃泌素失活中起重要作用。
