Pollak E W, Webber M M
Vasc Surg. 1976 Sep-Oct;10(4):214-8. doi: 10.1177/153857447601000403.
The incidence of mural thrombosis following three types of experimental intimal injuries at common carotid arteries, was investigated in a series of 12 dogs. Mural thrombosis was obtained at each of the intimal lesions. Moreover, obstructive thrombosis occurred in three instances. Further investigation of thrombi revealed that partial fragmentation occurred when exposed to hydrodynamic forces. These results suggest that mural thrombosis following carotid endarterectomy in humans, is possibly more frequent and significant than it is generally appreciated, thus leading to the consideration of postoperative anticoagulation after endarterectomy, as a means to minimize the incidence of postoperative embolic cerebrovascular accidents.
在一系列12只狗身上，研究了三种类型的颈总动脉实验性内膜损伤后壁血栓形成的发生率。在每个内膜损伤处均形成了壁血栓。此外，有3例发生了阻塞性血栓形成。对血栓的进一步研究表明，当暴露于流体动力时会发生部分破碎。这些结果表明，人类颈动脉内膜切除术后壁血栓形成可能比通常认为的更频繁、更严重，因此考虑在内膜切除术后进行抗凝治疗，作为降低术后栓塞性脑血管意外发生率的一种手段。
