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[血清素对大鼠自我刺激及条件性回避反应的影响]

[Effect of serotonin on self stimulation and conditioned avoidance reactions in rats].

作者信息

Boianovich V V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1976 Sep-Oct;26(5):1011-9.

PMID:997922
Abstract

It has been shown that serotonin influences self-stimulation and avoidance conditioned reactions in rats in a different way. Serotonin administration caused a reorganization of self-stimulation process and enhanced its frequency; the avoidance reaction grew weaker and was achieved with a longer latency. Alternation of stages of activation and inhibition was observed in the EEG of the neocortex, hypothalamus and hippocampus as well as shifts in the heart rate. These changes did not always correlate with the animals' behaviour. Unidirectional, yet different serotonin effects on various behavioral reactions, brain electrical activity and vegetative processes testify to a relative independence of their mechanisms.

摘要

研究表明,血清素以不同方式影响大鼠的自我刺激和回避条件反应。给予血清素会导致自我刺激过程的重组并提高其频率;回避反应减弱,且达到该反应的潜伏期延长。在新皮层、下丘脑和海马体的脑电图中观察到激活和抑制阶段的交替以及心率变化。这些变化并不总是与动物的行为相关。血清素对各种行为反应、脑电活动和植物性过程具有单向但不同的影响,这证明了它们机制的相对独立性。

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