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[通过腹膜液静脉浓缩回输治疗肝硬化腹水]

[Treatment of cirrhotic ascites by means of venous concentrated reinjected of the peritoneal fluid].

作者信息

Davcev P, Bidikov V, Vanovski B, Serafimoski V

出版信息

Acta Chir Iugosl. 1976;23(3):267-81.

PMID:998128
Abstract

Thanks to diuretics, adequate diet, and other measures, the treatment of cirrhotic ascites in recent years has brought better results. Nonetheless, a certain number of patients do not respond to the above mentioned treatment. Such patients are afflicted with so called Refractory Ascites on which diuretics have no effect. In recent years the concentrated continuous reinjection methods has been accepted. During a nine month period, we have treated and analyzed thirty patients with severe Hepatic Ascitogenic Cirrhosis. The results have shown: 8 patients with satisfactory improvement with one reinjection, in 2 patients Ascites did not reoccur; 6 patients died; 6 patients failed to return for a control reexamination; in 2 patients, ascites persisted even after repeated reinjections. The patients were given diuretics the third week following the reinjection, and were put on a low salt diet. Ascites reoccurred, and to a greater degree during the second third, and fourth month. A reduced sodium level was corrected by the reinjection and by the administration of NaCl during the reinjection. K and Cl levels did not change significantly. Urea levels, which were elevated in many cases were normalized. Ammoniums and Phenols also tended to normalize following reinjection. Bilirubin values were highly variable especially in two patients. One of whom had a severely damaged liver (direct bilirubin), the other of whom had bleeding varicoses of the esophagus (indirect bilirubin). Both of these patients died. In such cases reinjection should not be performed until the bilirubin values fall below 5 mgr %. Of the six patients who died, four died of unforeseen esophageal hemorrhaging. A larger number of patients grew more tolerant of diuretics. Preparation for a Portocaval Shunt with the reinjection method is of a special advantage because of an overall improvement in condition, making surgery possible. Complications resulting from reinjection were insignificant and transitory. As a whole, our results (sixteen patients in satisfactory condition), showed that Continuous Venous Reinjection of peritoneal fluid, even though a palliative method, represents a significant step forward in the treatment of Ascites in the severely ill.

摘要

由于利尿剂、合理饮食及其他措施,近年来肝硬化腹水的治疗取得了更好的效果。然而,仍有一定数量的患者对上述治疗无反应。这类患者患有所谓的顽固性腹水,利尿剂对其无效。近年来,浓缩连续回输法已被采用。在九个月的时间里,我们对30例重度肝源性肝硬化腹水患者进行了治疗和分析。结果显示:8例患者一次回输后腹水明显改善,2例腹水未再复发;6例患者死亡;6例患者未返回进行复查;2例患者即使多次回输腹水仍持续存在。回输后第三周给患者使用利尿剂,并给予低盐饮食。腹水在第二、三、四个月复发,且程度加重。回输及回输期间给予氯化钠可纠正钠水平降低。钾和氯水平无明显变化。许多病例中升高的尿素水平恢复正常。回输后铵和酚也趋于正常。胆红素值变化很大,特别是在两名患者中。其中一名患者肝脏严重受损(直接胆红素),另一名患者食管静脉曲张出血(间接胆红素)。这两名患者均死亡。在这种情况下,直到胆红素值降至5毫克%以下才应进行回输。在死亡的6例患者中,4例死于意外的食管出血。更多患者对利尿剂的耐受性增强。采用回输法为门腔分流术做准备具有特殊优势,因为整体状况改善,使手术成为可能。回输引起的并发症轻微且短暂。总体而言,我们的结果(16例患者情况良好)表明,即使腹膜液连续静脉回输是一种姑息性方法,但在重症腹水治疗中仍是显著的进步。

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