Biswas B, Ghosh J J
Adv Prostaglandin Thromboxane Res. 1976;1:381-6.
PGE2 increases NSM in the neurosecretory neurons and posterior pituitary store of HNNS. It stimulates acid phosphatase and TPPase activities in HT, indicating increased synthesis of NSM. PGE2 also increases AChE and BuChE activities. PGE1 shows very little effect on NSM distribution and enzyme activities. It is concluded that PGE2 causes increased HNNS activity by stimulating AChE-mediated and Ca2+-dependent "stimulation secretion coupling mechanism".
前列腺素E2增加神经分泌神经元中神经分泌物质（NSM）以及下丘脑神经垂体神经分泌系统（HNNS）后叶垂体储存中的NSM。它刺激下丘脑（HT）中酸性磷酸酶和焦磷酸酶的活性，表明NSM的合成增加。前列腺素E2还增加乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BuChE）的活性。前列腺素E1对NSM分布和酶活性几乎没有影响。得出的结论是，前列腺素E2通过刺激乙酰胆碱酯酶介导的和钙离子依赖性的“刺激-分泌偶联机制”导致HNNS活性增加。
