Forthomme D, Cantin M
Am J Pathol. 1976 Nov;85(2):263-76.
Unilaterally nephrectomized rats treated with deoxycorticosterone and 1% sodium chloride in their drinking water developed severe systemic hypertension with marked cardiac and renal lesions. No pathologic changes could be detected in the retinal vasculature by light microscopy, but electron microscopy revealed inconstant alterations in the pericytes of retinal capillaries: these cells showed hyaloplasmic edema, margination of chromatin, dilatation of rough endoplasmic reticulum, and swelling of mitochondria. Injection of lanthanum into control rats confirmed that this 40-A tracer cannot pass the interendothelial tight junctions. In hypertensive animals, however, it penetrated these junctions and could be visualized in capillary basement membranes and between cells of the retina. The results indicate that an increase in permeability is probably the first pathologic change to occur in the retinal capillaries of hypertensive rats.
单侧肾切除的大鼠饮用含脱氧皮质酮和1%氯化钠的水后，会出现严重的全身性高血压，并伴有明显的心脏和肾脏病变。通过光学显微镜在视网膜血管系统中未检测到病理变化，但电子显微镜显示视网膜毛细血管周细胞存在不恒定的改变：这些细胞表现为透明质水肿、染色质边缘化、粗面内质网扩张和线粒体肿胀。向对照大鼠注射镧证实，这种40埃的示踪剂不能通过内皮细胞间紧密连接。然而，在高血压动物中，它穿透了这些连接，并可在视网膜的毛细血管基底膜和细胞之间看到。结果表明，通透性增加可能是高血压大鼠视网膜毛细血管中发生的首个病理变化。
