Barbanti-Brodano G, Trabanelli C, Lazzarin L, Martini F, Merlin M, Calza N, Corallini A, Tognon M
Dipartimento di Medicina Sperimentale e Diagnostica, Università di Ferrara.
G Ital Med Lav Ergon. 1998 Oct-Dec;20(4):218-24.
Simian virus 40 (SV40) has been introduced into the human population with contaminated polio vaccines between 1955 and 1963. Previous research conducted by southern blot hybridization and recent analysis by PCR have shown the presence of SW0 sequences in human brain tumors, mesotheliomas and osteosarcomas as well as in normal tissues such as blood and sperm fluids. SV40 RNA and T antigen were detected in the same tissues. All the samples were coinfected by BK Virus (BKV), suggesting that BKV may have a helper function for SV40 replication in human cells. The presence of SV40 in human tumors suggests that the virus may be a cofactor in the etiopathogenesis of human neoplasia. In addition, blood and semen may represent the vectors for transmission of SV40 by horizontal infection in the human population.
1955年至1963年间，猴病毒40（SV40）随受污染的脊髓灰质炎疫苗进入人类群体。先前通过Southern印迹杂交进行的研究以及最近通过PCR进行的分析表明，在人脑肿瘤、间皮瘤和骨肉瘤以及血液和精液等正常组织中存在SV40序列。在相同组织中检测到了SV40 RNA和T抗原。所有样本均同时感染了BK病毒（BKV），这表明BKV可能对SV40在人类细胞中的复制具有辅助功能。SV40在人类肿瘤中的存在表明该病毒可能是人类肿瘤发病机制中的一个辅助因素。此外，血液和精液可能是SV40在人群中通过水平感染进行传播的载体。
