Kraus T, Haack M, Schuld A, Hinze-Selch D, Kühn M, Uhr M, Pollmächer T
Max Planck Institute of Psychiatry, Munich, Germany.
Am J Psychiatry. 1999 Feb;156(2):312-4. doi: 10.1176/ajp.156.2.312.
Leptin is produced by fat cells and is presumed to signal the size of the adipose tissue to the brain. The authors investigated whether antipsychotic drugs that often induce weight gain affect circulating levels of leptin.
Weight, body mass index, and leptin plasma level were measured weekly over 4 weeks in psychiatric inpatients who received clozapine (N = 11), olanzapine (N = 8), haloperidol (N = 13), or no psychopharmacological treatment (N = 12).
In patients receiving clozapine or olanzapine, significant increases in weight, body mass index, and leptin level were found, whereas these measures remained stable in patients who received haloperidol or no pharmacological treatment.
Weight gain induced by clozapine or olanzapine appears to be associated with an increase in leptin level that cannot be attributed to dietary changes upon hospitalization.
瘦素由脂肪细胞产生，被认为是向大脑传递脂肪组织大小的信号。作者研究了经常导致体重增加的抗精神病药物是否会影响循环中的瘦素水平。
对接受氯氮平（N = 11）、奥氮平（N = 8）、氟哌啶醇（N = 13）或未接受精神药物治疗（N = 12）的精神科住院患者，在4周内每周测量体重、体重指数和血浆瘦素水平。
接受氯氮平或奥氮平治疗的患者，体重、体重指数和瘦素水平显著增加，而接受氟哌啶醇治疗或未接受药物治疗的患者这些指标保持稳定。
氯氮平或奥氮平引起的体重增加似乎与瘦素水平升高有关，这不能归因于住院期间的饮食变化。
