Hollander E, DelGiudice-Asch G, Simon L, Schmeidler J, Cartwright C, DeCaria C M, Kwon J, Cunningham-Rundles C, Chapman F, Zabriskie J B
Department of Psychiatry and the Seaver Autism Research Center, Mt. Sinai School of Medicine, New York, NY 10029-6574, USA.
Am J Psychiatry. 1999 Feb;156(2):317-20. doi: 10.1176/ajp.156.2.317.
Monoclonal antibody D8/17 identifies a B lymphocyte antigen with expanded expression in rheumatic fever, Sydenham's chorea, and subgroups of obsessive-compulsive disorder and Tourette's syndrome with repetitive behaviors. The authors examined the rate of D8/17 expression in children with autism and its correlation with severity of repetitive behaviors.
Blood samples from 18 patients with autism and 14 comparable medically ill children were evaluated for percentage of D8/17-positive B cells by immunofluorescence and for streptococcal antibodies. Severity of repetitive behaviors was also determined.
The frequency of individuals with > or =11% D8/17-positive cells was significantly higher in the autistic patients (78%) than the comparison subjects (21%), severity of repetitive behaviors significantly correlated with D8/17 expression, and D8/17-positive patients had significantly higher compulsion scores than D8/17-negative patients.
D8/17 expression is high in patients with autism and may serve as a marker for compulsion severity within autism.
单克隆抗体D8/17可识别一种B淋巴细胞抗原，其在风湿热、 Sydenham舞蹈病以及伴有重复行为的强迫症和抽动秽语综合征亚组中表达增加。作者研究了自闭症患儿中D8/17的表达率及其与重复行为严重程度的相关性。
通过免疫荧光法评估18例自闭症患儿和14例病情相当的患病儿童的血样中D8/17阳性B细胞的百分比，并检测链球菌抗体。同时确定重复行为的严重程度。
自闭症患者中D8/17阳性细胞≥11%的个体频率（78%）显著高于对照组（21%），重复行为的严重程度与D8/17表达显著相关，且D8/17阳性患者的强迫评分显著高于D8/17阴性患者。
自闭症患者中D8/17表达较高，可能作为自闭症内强迫严重程度的一个标志物。
