Evidence for protein splicing in the endoplasmic reticulum-Golgi intermediate compartment.
作者信息
Demirov D, Sarafian V, Kremensky I, Ganev V
机构信息
Department of Chemistry and Biochemistry, Medical University, Sofia, Bulgaria.
出版信息
Biochim Biophys Acta. 1999 Jan 11;1448(3):507-11. doi: 10.1016/s0167-4889(98)00158-x.
PMID:9990302
Abstract
We present evidence that the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is a site for protein splicing of cathepsin C: (i) maturation of the enzyme in COS 7 cells is a two-step process starting within the ERGIC, and (ii) the intermediately processed polypeptide retains both termini of the proenzyme and lacks an internal fragment.
摘要
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