Demirov D, Sarafian V, Kremensky I, Ganev V
Department of Chemistry and Biochemistry, Medical University, Sofia, Bulgaria.
Biochim Biophys Acta. 1999 Jan 11;1448(3):507-11. doi: 10.1016/s0167-4889(98)00158-x.
We present evidence that the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is a site for protein splicing of cathepsin C: (i) maturation of the enzyme in COS 7 cells is a two-step process starting within the ERGIC, and (ii) the intermediately processed polypeptide retains both termini of the proenzyme and lacks an internal fragment.
