通过固相有机合成获得的甘氨酸甜菜碱类似物对苜蓿中华根瘤菌的毒性和渗透保护活性。
Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti.
作者信息
Cosquer A, Pichereau V, Le Mée D, Le Roch M, Renault J, Carboni B, Uriac P, Bernard T
机构信息
Université de Rennes 1, Groupe Membranes et Osmorégulation, UPRES-A CNRS 6026, Rennes-France.
出版信息
Bioorg Med Chem Lett. 1999 Jan 4;9(1):49-54. doi: 10.1016/s0960-894x(98)00679-9.
Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti.
通过使用王氏树脂的固相合成法（SPOS）获得了七种细菌渗透保护剂甘氨酸甜菜碱（GB，三甲基铵乙酸盐）的类似物，其中Me3N+部分的甲基被各种取代基取代。它们的生物活性（渗透保护与毒性）似乎与其在甜菜碱去甲基化模式细菌苜蓿中华根瘤菌中的摄取效率及其分解代谢密切相关。
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