Fishman V M, Murav'eva S A, Lokshin G B, Shenin Iu D, Astashkina V L
Antibiotiki. 1976 Oct;21(10):867-72.
The basic points in the development of a specialized computer information search system providing ientification of new antibiotics at early stages of their investigation are described. The system of coding the physico-chemical properties of the agents and the spectra of their antimicrobial activity presenting the substance in the information bank is developed. The task of identification is to find in the reference bank according to some specially organized keys such antibiotics which are identical or close by their properties to the substance being identified. Mini-computer of M-6000 type is used as the technical base of the information search system. Preliminary organization of the bank specified by the coding system markedly reduces the requirements to the computer operative memory.
描述了在新抗生素研究的早期阶段开发用于识别新抗生素的专业计算机信息搜索系统的基本要点。开发了一种对药物的物理化学性质及其抗菌活性谱进行编码的系统,以便将该物质存入信息库。识别的任务是根据一些特别编制的索引,在参考库中查找那些在性质上与被识别物质相同或相近的抗生素。采用M - 6000型小型计算机作为信息搜索系统的技术基础。由编码系统规定的库的初步组织显著降低了对计算机操作内存的要求。