Shorin V A, Averbukh L A
Antibiotiki. 1976 Oct;21(10):914-9.
The variants of the tumor cells of Fisher lymphadenosis, strain L-5178 and Staph. aureus resistant to rubomycin simultaneously became partially less sensitive to adriamycin. Sensitivity to karminomycin in the rubomycin resistant strains did not practically change as compared to the sensitivity of the initial strains. Sensitivity to adriamycin and rubomycin in Staph. aureus decreased 67 and 4 times respectively after 7 passages on media with increasing concentrations of adriamycin, while sensitivity to karminomycin decreased only 1.5 times, i.e. remained practically unchanged. After 22 passages of Staph. aureus to karminomycinrubomycin and adriamycin decreased 16, 67 and 33 times respectively. The results of the study may be explained by differences in the changes of the cell membrane permeability due to the drug effect.
费希尔淋巴结病L - 5178菌株的肿瘤细胞变体以及对柔红霉素耐药的金黄色葡萄球菌同时对阿霉素的敏感性部分降低。与初始菌株相比，柔红霉素耐药菌株对卡米诺霉素的敏感性实际上没有变化。在含有浓度递增的阿霉素的培养基上传代7次后，金黄色葡萄球菌对阿霉素和柔红霉素的敏感性分别降低了67倍和4倍，而对卡米诺霉素的敏感性仅降低了1.5倍，即实际上保持不变。金黄色葡萄球菌传代22次至卡米诺霉素后，对柔红霉素和阿霉素的敏感性分别降低了16倍、67倍和33倍。该研究结果可能是由于药物作用导致细胞膜通透性变化的差异所致。
