Nurazian A G
Antibiotiki. 1976 Aug;21(8):737-41.
Chlortetracycline was administered to the rabbits per os in a single dose of 150000 Units/kg. After 29-30 days of pregnancy the rabbits were sacrificied 1--3--6--9--12--24-hours and 2--3--4 days after the drug administration. Three-four rabbits were examined in every experiment. The antibiotic levels were determined by the agar-diffusion method. It was found that chlortetracycline was present in bactericidal concentrations in all 60 tissues of the rabbits and fetus examined except the rabbits eye lens. In some tissues of the rabbit and fetus chlortetracycline persisted up to 3 and 2 days respectively. The antibiotic levels in the organs, tissues and fluids of the fetus were many times lower than those in the rabbits. The concentration peak in the fetus was attained somewhat later and the rate of the concentration decrease was lower as compared to the same indices in the rabbit. The highest concentrations of chlortetracycline in the fetus were registered in the amniotic membranes, joints, bones, urine and amniotic fluid.
给兔子口服金霉素，剂量为150000单位/千克，单次给药。在妊娠29 - 30天后，于给药后1、3、6、9、12、24小时以及2、3、4天处死兔子。每次实验检查3 - 4只兔子。采用琼脂扩散法测定抗生素水平。结果发现，在所检查的兔子和胎儿的所有60个组织中，除兔眼晶状体外，金霉素均以杀菌浓度存在。在兔子和胎儿的某些组织中，金霉素分别持续存在3天和2天。胎儿器官、组织和体液中的抗生素水平比兔子体内的低很多倍。与兔子的相同指标相比，胎儿体内的浓度峰值出现得稍晚，浓度下降速度也较慢。胎儿中金霉素浓度最高的部位是羊膜、关节、骨骼、尿液和羊水。
