Nurazian A G
Antibiotiki. 1976 Jul;21(7):625-30.
Neomycin was administered intramuscularly to rabbits in single doses of 50000 gamma/kg 24--25-day gravid rabbits were sacrificed 1.5-2-3-4-6-12-24 hours and 2-3-6 days after the drug administration. 3--4 rabbits were used in every experiment. The antibiotic concentration was determined with the agar-diffusion method. It was found that the drug was present in various bactericidal concentrations in all 55 organs, tissues and fluids of the rabbits and the fetus examined except the crystalline lens in the rabbits and the brain, liver and bile cyst of the fetus. In some material of the rabbits and their fetus, high levels of neomycin were detected during 6 days, i. e. up to the end of the experiment. The highest neomycin levels in the organs, tissues and fluids of the fetus were detected somewhat later than in those of the rabbits. However, their retention time was longer. It is necessary to forbear from using antibiotics, such as neomycin, monomycin and others, which retained for long periods of time in the organism.
将新霉素以50000微克/千克的单剂量肌肉注射给家兔。对怀孕24 - 25天的家兔在给药后1.5、2、3、4、6、12、24小时以及2、3、6天进行处死。每次实验使用3 - 4只家兔。采用琼脂扩散法测定抗生素浓度。结果发现，在所检测的家兔及胎儿的所有55个器官、组织和体液中，除家兔的晶状体以及胎儿的脑、肝和胆囊外，均存在各种杀菌浓度的该药物。在一些家兔及其胎儿的样本中，在6天内即直至实验结束都检测到了高水平的新霉素。胎儿的器官、组织和体液中检测到的新霉素最高水平比家兔的稍晚出现。然而，其保留时间更长。有必要避免使用在体内长时间留存的抗生素，如新霉素、莫能霉素等。
