Breza T, Taylor R, Eaglstein W H
Arch Dermatol. 1976 Sep;112(9):1256-8.
Sequential topical application of fluorouracil and 0.5% triamcinolone acetonide cream is as effective in the treatment of actinic keratoses as fluorouracil alone, but the combination obviates the unpleasent irritation caused by fluorouracil. Diluted (0.1%) triamcinolone acetonide cream preparations are ineffective in the suppression of the associated inflammation. There is no detectable difference in the number of new actinic keratoses between the combination therapy and fluorouracil alone. These findings demonstrate that the degree of success with fluorouracil therapy in actinic keratosis is not related to the degree of inflammation associated with the treatment and are consistent with a chemotherapeutic explanation of fluorouracil's effect on actinic keratosis.
序贯局部应用氟尿嘧啶和0.5%曲安奈德乳膏治疗光化性角化病的效果与单独使用氟尿嘧啶相同，但联合使用可避免氟尿嘧啶引起的不适刺激。稀释（0.1%）的曲安奈德乳膏制剂在抑制相关炎症方面无效。联合治疗组与单独使用氟尿嘧啶组之间新出现的光化性角化病数量没有可检测到的差异。这些发现表明，氟尿嘧啶治疗光化性角化病的成功程度与治疗相关的炎症程度无关，并且与氟尿嘧啶对光化性角化病作用的化疗解释一致。
