Wenzlik R, Klinger W
Arch Int Pharmacodyn Ther. 1976 Sep;223(1):155-61.
Sleeping times in male and femal rats are prolonged after the simultaneous i.p. administration of adrenaline and hexobarbital sodium. The blood concentration of hexobarbital at awakening is unchanged in male rats, while in females this concentration is decreased. When adrenaline is given s.c., no change in sleeping times is observed in female and male rats, while the blood concentration of hexobarbital for the two sexes is decreased. Glucose, given p.o. or i.p., has no influence on sleeping times or on hexobarbital concentrations. The hexobarbital concentrations at awakening is higher in female than in male rats.
腹腔注射肾上腺素和己巴比妥钠后，雄性和雌性大鼠的睡眠时间延长。雄性大鼠苏醒时己巴比妥的血药浓度未变，而雌性大鼠该浓度降低。皮下注射肾上腺素时，雄性和雌性大鼠的睡眠时间均无变化，但两性的己巴比妥血药浓度均降低。口服或腹腔注射葡萄糖对睡眠时间和己巴比妥浓度均无影响。雌性大鼠苏醒时的己巴比妥浓度高于雄性大鼠。
