Brandt K D, Palmoski M J, Perricone E
Arthritis Rheum. 1976 Nov-Dec;19(6):1308-14. doi: 10.1002/art.1780190611.
Proteoglycan aggregates isolated from normal bovine knee cartilage were larger than those from osteoarthritic cartilage of the same joints and appeared relatively more resistant to digestion with leech hyaluronidase. Incubation of proteoglycan subunits from the arthritic cartilage with hyaluronic acid resulted in marked aggregation, comparable in magnitude to that shown by subunits from normal cartilage. The results indicate that the hyaluronate-binding region of these proteoglycans was functionally intact and suggest that diminished aggregation of proteoglycans in osteoarthritic cartilage may be due to an abnormality in some other constituent of the aggregates.
从正常牛膝关节软骨中分离出的蛋白聚糖聚集体比同一关节骨关节炎软骨中的聚集体更大，并且似乎对水蛭透明质酸酶的消化更具抵抗力。将骨关节炎软骨中的蛋白聚糖亚基与透明质酸一起孵育会导致明显的聚集，其程度与正常软骨中的亚基相当。结果表明，这些蛋白聚糖的透明质酸结合区域功能完好，并表明骨关节炎软骨中蛋白聚糖聚集减少可能是由于聚集体中某些其他成分异常所致。
