Palmoski M, Brandt K
Clin Chim Acta. 1976 Jul 1;70(1):87-95. doi: 10.1016/0009-8981(76)90008-5.
The ability of proteoglycans from hip cartilage of a patient with osteoarthritis to bind hyaluronic acid was examined. Proteoglycans from areas showing severe morphologic changes of the disease showed no interaction with hyaluronic acid in vitro. Moreover, fractions which normally contain aggregated proteoglycans were no larger in hydrodynamic size than disaggregated proteoglycans, suggesting that the proteoglycans from these regions were not aggregated in vivo. Proteoglycans from less extensively diseased areas, in contrast, underwent aggregation in vitro and appeared to have been aggregated by tissue hyaluronic acid in vivo. The results suggest that the progressive morphologic changes of osteorthritis are associated with progressive defects in proteoglycan aggregation due, at least in part, to impaired ability of the proteoglycans to interact with hyaluronic acid.
对一名骨关节炎患者髋部软骨蛋白聚糖结合透明质酸的能力进行了检测。来自疾病形态学改变严重区域的蛋白聚糖在体外未显示与透明质酸有相互作用。此外，通常含有聚集蛋白聚糖的组分在流体动力学尺寸上并不比解聚的蛋白聚糖大，这表明来自这些区域的蛋白聚糖在体内未发生聚集。相比之下，来自病变程度较轻区域的蛋白聚糖在体外会发生聚集，并且在体内似乎已被组织中的透明质酸聚集。结果表明，骨关节炎的渐进性形态学改变与蛋白聚糖聚集的渐进性缺陷有关，这至少部分是由于蛋白聚糖与透明质酸相互作用的能力受损所致。
