Koukkou M, Lehmann D
Biol Psychiatry. 1976 Dec;11(6):663-77.
EEG correlates of subjective experiences induced by delta9-trans-tetrahydrocannabinol (THC) and EEG correlates of individual disposition to such experiences were investigated. Twelve normal volunteers took 200 mug/kg THC orally. The subjects were asked to signal subjective experiences. The EEG was analyzed (period analysis) before and repeatedly after THC injestion, during resting, attention, eye closure, visual hallucinations, and body image disturbances. EEG frequency spectra differed significantly between resting and visual hallucinations and body image disturbances. The differences included slower alpha and more theta during THC experiences, reminiscent of initial drowsiness EEG, and of some results in schizophrenia. The differences between spectra during visual hallucinations and during body image disturbances indicate different functional brain states. Subjects with a high tendency to cannabinol induced experiences exhibited resting spectra before and after THC with higher modal alpha frequences (reminiscent of subjects with high neuroticism scores) than subjects with a low tendency.
研究了δ9-反式-四氢大麻酚（THC）诱发的主观体验的脑电图相关性以及个体对此类体验的易感性的脑电图相关性。12名正常志愿者口服200微克/千克THC。要求受试者报告主观体验。在服用THC之前和之后反复进行脑电图分析（周期分析），分析在静息、注意力集中、闭眼、视幻觉和身体意象障碍期间的脑电图。静息状态与视幻觉及身体意象障碍状态下的脑电图频谱存在显著差异。这些差异包括在THC体验期间α波较慢且θ波较多，这让人联想到最初的困倦脑电图，以及精神分裂症的一些结果。视幻觉期间和身体意象障碍期间频谱的差异表明大脑功能状态不同。相较于易感性较低的受试者，对大麻酚诱发体验易感性较高的受试者在服用THC前后的静息频谱具有更高的α波模态频率（让人联想到神经质得分高的受试者）。
