Deniker P, Ginestet D, Etevenon P, Peron-magnan P
Encephale. 1975;1(1):33-41.
Moreau de Tours's classical studies about haschisch had pointed out to a rich symptomatology: visual and auditive hallucinations preceded by the "primordial effect": "the dissociation of ideas". This delirious state was assimilated to dream. Modern studies, conducted with Delta-9-THC, in healthy voluntaries, again suggest the comparison or even the identity of the modifications caused by cannabis with sleep and dream. 10 mg of Delta-9-THC was absorbed in sesame oil by the voluntaries, and all of them presented disturbances of their vigilance, changes of their mood, now with euphoris and now with dysphoria, and slight psycho-sensorial alterations. The voluntaries EEG showed important and specific individual reactivity. Three subjects presented an arousal tendency, three other a greater towards sleep. Slight morphological changes have appeared, such as desynchronised periods, rapid shifts between I A, I B, II stages of sleep or an hypovariable I B stage of sedation with period of occular movements resembling to REM-stage.
莫罗·德·图尔关于大麻的经典研究指出了丰富的症状表现：在“原初效应”（即“观念解离”）之前出现视觉和听觉幻觉。这种谵妄状态被等同于梦境。现代对健康志愿者使用Δ⁹-四氢大麻酚进行的研究再次表明，大麻引起的改变与睡眠和梦境存在相似之处甚至相同。志愿者们将10毫克的Δ⁹-四氢大麻酚溶于芝麻油中服用，所有人都出现了警觉性障碍、情绪变化，时而欣快时而烦躁不安，以及轻微的心理感觉改变。志愿者的脑电图显示出重要且特定的个体反应性。三名受试者表现出觉醒倾向，另外三名则更倾向于睡眠。出现了轻微的形态学变化，如去同步化时期、睡眠I A、I B、II期之间的快速转换，或I B期镇静的低变异性以及类似快速眼动期的眼球运动期。
