Doust J W, Kolesar G S, Dixon L M
Biol Psychiatry. 1976 Dec;11(6):697-707.
Estimation of blood transit time in the neck and the extension of this into the head was made by a method of electrical impedance, over a wide age range, in 159 healthy subjects, 160 schizophrenic patients, and 199 patients with organic brain disease. In each case, the distance between the electrocardiogram and the next succeeding pulse-volume impedance wave was measured and averaged over 30 serial wave forms. Chronological age proved a significant variable, transit times lengthening progressively with the age, but only for measurements extending into the head. Sex and hemispheric laterality played no significant role. With age held constant, mean transit times into the head were significantly prolonged in both groups of patients as compared with controls. No significant differences were found however between means of psychiatric andneurological patients. It is suggested that these results reinforce the organic etiology of schizophrenia.
采用电阻抗法，在较宽年龄范围内，对159名健康受试者、160名精神分裂症患者和199名器质性脑疾病患者，测量了颈部的血液通过时间及其向头部的延伸情况。在每种情况下，测量心电图与下一个连续脉搏容积阻抗波之间的距离，并在30个连续波形上进行平均。实际年龄被证明是一个显著变量，通过时间随年龄逐渐延长，但仅在延伸至头部的测量中如此。性别和半球偏侧性未发挥显著作用。在年龄保持不变的情况下，与对照组相比，两组患者头部的平均通过时间均显著延长。然而，精神科患者和神经科患者的平均值之间未发现显著差异。有人认为，这些结果强化了精神分裂症的器质性病因。
