Hutter O, Duckert F, Fridrich R, Gruber U F
Dtsch Med Wochenschr. 1976 Dec 10;101(50):1834-7. doi: 10.1055/s-0028-1104348.
The effectiveness of 4 X 500 ml dextran-40 infusions (Rheomacrodex) for the prevention of postoperative deep vein thrombosis was evaluated in a prospective, controlled, randomized study in urological and general surgical patients. The 125I-fibrinogen test was performed daily in all patients. 36 of 100 control patients developed deep vein thrombosis, but only 20 out of 92 (21.7%) did so in the dextran group (P less than 0.05). The number of patients showing bilateral deep vein thrombosis was significantly reduced under dextran prophylaxis (P less than 0.01). No side effects of dextran prophylaxis were seen.
在一项针对泌尿外科和普通外科患者的前瞻性、对照、随机研究中，评估了4次输注500毫升右旋糖酐-40（低分子右旋糖酐）预防术后深静脉血栓形成的有效性。对所有患者每日进行¹²⁵I-纤维蛋白原试验。100例对照患者中有36例发生深静脉血栓形成，但在右旋糖酐组的92例患者中只有20例（21.7%）发生（P<0.05）。在右旋糖酐预防治疗下，出现双侧深静脉血栓形成的患者数量显著减少（P<0.01）。未观察到右旋糖酐预防治疗的副作用。
