右旋糖酐70预防术后静脉血栓形成。一项对照试验。
Dextran 70 in prophylaxis of postoperative venous thrombosis. A controlled trial.
作者信息
Lambie J M, Barber D C, Dhall D P, Matheson N A
出版信息
Br Med J. 1970 Apr 18;2(5702):144-5. doi: 10.1136/bmj.2.5702.144.
Abstract
A controlled prospective trial was carried out in a group of 80 women undergoing gynaecological surgery and thought to be at risk of developing postoperative venous thrombosis. The patients, who had been randomly allocated to prophylaxis with either dextran 70 or warfarin, were well matched in age, weight and other predisposing factors.In the warfarin group, 12 out of 40 patients developed deep vein thrombosis, six of these episodes being classified as major and six as minor. In the dextran 70 group, 4 out of 40 patients developed deep vein thrombosis, all of them minor. The protective effect of dextran 70 is significantly better than that of warfarin (P<0.01) as used in the present study.
摘要
对一组80名接受妇科手术且被认为有术后发生静脉血栓风险的女性进行了一项对照前瞻性试验。这些患者被随机分配接受右旋糖酐70或华法林预防治疗，在年龄、体重和其他易感因素方面匹配良好。在华法林组，40名患者中有12名发生深静脉血栓形成，其中6例被分类为严重，6例为轻微。在右旋糖酐70组，40名患者中有4名发生深静脉血栓形成，均为轻微。本研究中使用的右旋糖酐70的保护作用明显优于华法林（P<0.01）。
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