Davies C T, Brotherhood J R, Few J D, Zeidifard E
Eur J Appl Physiol Occup Physiol. 1976 Dec 6;36(1):49-56. doi: 10.1007/BF00421633.
The changes in plasma catecholamine concentration (deltaC) following beta-blockade (practolol, 15 mg) and atropinisation (Atropine, 1.8 mg) have been studied on 5 healthy male subjects during exercise on a motor driven treadmill. The results showed that for a given V-2 and % VO2 max, beta blockade was without effect on delta C (except in one athletic subject, but atropine produced a rise in deltaC. In relation to Q, both drugs produced an increase in deltaC, but for a given cardiac frequency (fH) deltaC was higher with beta blockade, and lower with atropinisation than found in control experiments. The intra- and inter-subject variability of delta C in relation of fH was resolved by considering the change in cardiac frequency calculated from baseline value obtained during walking at 6.44 km/h on the level, and expressed as a percentage of the maximal fH attainable for given individuals under the different drug and control conditions (%deltafH). It was concluded that during short term exercise, the rise of deltaC in relation to %deltafH reflects both the myocardial sensitivity to vagal and beta blockade, and the circulatory vasoconstrictor control of blood vessels which is required to sustain increases in systemic and muscle blood flow.
对5名健康男性受试者在电动跑步机上运动期间，给予β受体阻滞剂（心得宁，15毫克）和阿托品化（阿托品，1.8毫克）后血浆儿茶酚胺浓度变化（ΔC）进行了研究。结果表明，对于给定的V-2和最大摄氧量百分比，β受体阻滞剂对ΔC无影响（一名运动员受试者除外），但阿托品使ΔC升高。关于心输出量（Q），两种药物均使ΔC增加，但对于给定的心率（fH），β受体阻滞剂时的ΔC高于对照实验，而阿托品化时的ΔC低于对照实验。通过考虑根据在水平面上以6.44公里/小时行走时获得的基线值计算出的心率变化，并将其表示为给定个体在不同药物和对照条件下可达到的最大心率的百分比（%ΔfH），解决了fH相关的ΔC在受试者内和受试者间的变异性问题。得出结论，在短期运动期间，与%ΔfH相关的ΔC升高既反映了心肌对迷走神经和β受体阻滞剂的敏感性，也反映了维持全身和肌肉血流增加所需的血管循环血管收缩控制。
