Few J D, Davies C T
Eur J Appl Physiol Occup Physiol. 1980;43(3):221-8. doi: 10.1007/BF00421835.
The effects of atropine upon changes in the circulating levels of growth hormone (GH), cortisol, lactate, glucose, and free fatty acids (FFA) were studied during exercise using both constant and progressively increasing work loads. At low work loads, atropine had no effect upon the changes in either cortisol or lactate levels, but the normal exercise-induced rise in GH was abolished or markedly reduced. At higher work loads, especially when prolonged, the usual rises in cortisol and lactate were enhanced by atropine, but the rise in GH was diminished and delayed. In no circumstances were the changes in FFA or glucose significantly affected by atropine. We regard the effect of atropine upon changes in cortisol and lactate responses as secondary to its cardiovascular effect, but suggest that the inhibition of Gh release may be evidence of a cholinergic mechanism in the control of Gh release during exercise.
在运动过程中，采用恒定负荷和逐渐增加负荷两种方式，研究了阿托品对生长激素（GH）、皮质醇、乳酸、葡萄糖和游离脂肪酸（FFA）循环水平变化的影响。在低负荷运动时，阿托品对皮质醇或乳酸水平的变化没有影响，但运动诱导的正常GH升高被消除或显著降低。在较高负荷运动时，尤其是长时间运动时，阿托品增强了皮质醇和乳酸的通常升高，但GH的升高减弱且延迟。在任何情况下，FFA或葡萄糖的变化均未受到阿托品的显著影响。我们认为阿托品对皮质醇和乳酸反应变化的影响是其心血管效应的继发作用，但提示抑制GH释放可能是运动期间控制GH释放的胆碱能机制的证据。
