Moroder L, Wackerle L, Wünsch E
Hoppe Seylers Z Physiol Chem. 1976 Nov;357(11):1647-50.
1-Adamantyl fluoroformate was prepared from 1-adamantol and fluorophosgene. The cristalline and stable fluoroformate was allowed to react with amino acids to give the corresponding 1-adamantyloxycarbonyl derivatives in consistently high yields. Additonally this new reagent proved to be ideally reactive for acylation of the imidazol function of histidine and histidyl-peptides.
1-金刚烷基氟甲酸酯由1-金刚醇和氟光气制备而成。这种结晶且稳定的氟甲酸酯与氨基酸反应，能始终如一地高产率生成相应的1-金刚烷氧基羰基衍生物。此外，这种新试剂被证明对组氨酸和组氨酸肽的咪唑官能团进行酰化反应具有理想的反应活性。
