Kharkevich D A, Skoldinov A P
Biull Eksp Biol Med. 1975 May;79(5):71-5.
In the series of polymethylene bis-ammonium salts R(CH3)2N(CH2)NN(CH3)2R . 2I--(R=CH3 or Ad) a study was made of the significance of hydrophobic 1-adamantyle radicals (1--Ad) for curare-like activity. Administration of 1-ad radicals into the cation groups of depolarizing agents (n-9--11) altered their mechanism of action and diminished their activity. Attachmeni of 1-Ad radicals to the both quarternary nitrogen atoms of the antidepolarizing agents (n=5 and 6) sharply increased their curare-like activity. The data obtained pointed to the presence of hydrophobic zones in the cholinoreceptors of skeletal muscles.
在聚亚甲基双铵盐系列R(CH₃)₂N(CH₂)NN(CH₃)₂R·2I⁻（R = CH₃或Ad）中，研究了疏水性1-金刚烷基团（1-Ad）对箭毒样活性的意义。将1-Ad基团引入去极化剂的阳离子基团（n = 9 - 11）中会改变其作用机制并降低其活性。将1-Ad基团连接到抗去极化剂的两个季氮原子上（n = 5和6）会显著提高其箭毒样活性。所获得的数据表明骨骼肌胆碱能受体中存在疏水区。
