Gihani M T, Williams J M
Department of Chemistry, University of Bath, Claverton, Down Bath BA2 7AYUK.
Curr Opin Chem Biol. 1999 Feb;3(1):11-5. doi: 10.1016/s1367-5931(99)80003-9.
The use of transition-metal-enzyme combinations to effect tandem in situ racemisation and resolutions has extended the scope of dynamic kinetic resolutions. This methodology has signalled a more proactive stance to the racemisation process, which has traditionally relied on more fortuitous approaches, namely the exploitation of labile substrates. The development and application of specific racemising enzymes such as mandelate racemase offers potential for future multienzyme dynamic kinetic resolutions.
使用过渡金属 - 酶组合来实现串联原位外消旋化和拆分扩展了动态动力学拆分的范围。这种方法表明了对外消旋化过程采取更积极主动的立场，传统上该过程依赖于更偶然的方法，即利用不稳定的底物。特定外消旋酶如扁桃酸外消旋酶的开发和应用为未来的多酶动态动力学拆分提供了潜力。
