de Zeeuw R A
Department of Analytical Chemistry and Toxicology, University Centre for Pharmacy, Groningen, The Netherlands.
Toxicol Lett. 1998 Dec 28;102-103:103-8. doi: 10.1016/s0378-4274(98)00293-8.
When considering the state of the art in toxicology from an analytical perspective, the key developments relate to three major areas. (1) Forensic horizon: Today forensic analysis has broadened its scope dramatically, to include workplace toxicology, drug abuse testing, drugs and driving, doping, environmental and veterinary toxicology, etc. (2) Basic analytical issues, focusing on a strongly widening array of relevant substances and metabolites at ever decreasing levels in a large variety of matrices. (3) Validation and interpretation: Because forensic analyses may have severe, punitive consequences, validation of methods and approaches plus proficiency testing are of utmost importance. Also, interpretation of the analytical results must be done with prudence in view of chemical and biological diversity in society. This review discusses the various pros and cons in these developments.
从分析角度审视毒理学的当前技术水平时，关键进展涉及三个主要领域。（1）法医视野：如今，法医分析的范围已大幅拓宽，涵盖职业毒理学、药物滥用检测、药物与驾驶、兴奋剂检测、环境和兽医毒理学等。（2）基础分析问题，聚焦于在大量基质中，相关物质和代谢物种类急剧增加且含量不断降低的情况。（3）验证与解释：由于法医分析可能产生严重的惩罚性后果，方法和途径的验证以及能力验证至关重要。此外，鉴于社会中的化学和生物多样性，对分析结果的解释必须谨慎。本综述讨论了这些进展中的各种利弊。
