Reichardt H M, Schütz G
Division of Molecular Biology of the Cell I, German Cancer Resarch Center, Heidelberg.
Mol Cell Endocrinol. 1998 Nov 25;146(1-2):1-6. doi: 10.1016/s0303-7207(98)00208-1.
Recent advances in molecular genetics have brought us closer to answering the question as to which mechanisms are used by steroid hormone receptors to control transcription. While binding to specific response elements in the promoter and enhancer regions of many genes has for a long time been considered as the major mode of action, a growing number of alternative transcriptional control mechanisms have been identified in the last couple of years. With the recent finding that DNA binding of the glucocorticoid receptor is not essential for survival, mechanisms depending on cross-talk with other transcription factors through protein-protein interactions have gained attention. In this mini-review, we will discuss the roles of DNA binding-dependent and -independent transcriptional modes of action in development and physiology as exemplified by the analysis of glucocorticoid receptor function.
分子遗传学的最新进展让我们更接近于回答类固醇激素受体利用哪些机制来控制转录这一问题。长期以来，人们一直认为与许多基因启动子和增强子区域的特定反应元件结合是主要作用方式，但在过去几年中，已发现越来越多其他的转录控制机制。鉴于最近发现糖皮质激素受体的DNA结合对生存并非必不可少，通过蛋白质-蛋白质相互作用与其他转录因子发生串扰的机制受到了关注。在这篇小型综述中，我们将以糖皮质激素受体功能分析为例，讨论依赖DNA结合和不依赖DNA结合的转录作用模式在发育和生理学中的作用。
